Biochemistry of the T-Virus

So the Hokage said to make our blog “pop”. So yes, I am very serious when I say I’m gonna do the Biochem of the T-virus (or as much of it as I possibly can)

This will be short though, since it has more to do with genetics, but I’ll try to relate it to Biochemistry as much as possible.

The T-virus, known to all us gamers and movie fans as the cause of the zombie epidemic in the Resident Evil series, works like any other virus; i.e. it invades the host’s cells, destroys them when they are done replicating and then starts the process all over again.

The virus however, also destroys the mitochondria and uses a replica of itself to produce energy.

Bad move T-virus. We know that the majority of our ATP is produced by the Electron Transport Chain in the mitochondria and without it, you’re just gonna get 2ATP from glycolysis(which takes place in the cytosol), and that’s not nearly enough to power the brain and all the basic bodily functions. Thus the living subject loses all higher brain function, leaving just the cerebellum working which allows for (rather poor) movement. The hormones of the hypothalamus are also not regulated and floods the blood stream leading to rage and hunger.

This also explains why zombies still bleed. The virus doesn’t target erythrocytes because they have no organelles to allow them to reproduce, and they also have no mitochondria to destroy since they get all their energy from glycolysis which is kept going due to the production of lactate which regenerates the NAD+ needed.

In other words, if the Umbrella Cooperation had engineered the virus to leave the mitochondria alone, they might have made a very powerful viral weapon, and could have possibly made more controllable subjects.


This entry was posted in Biochemistry and tagged , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s